Identification of mammalian arginyltransferases that modify a specific subset of protein substrates.

@article{Rai2005IdentificationOM,
  title={Identification of mammalian arginyltransferases that modify a specific subset of protein substrates.},
  author={Reena Rai and Anna Kashina},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 29},
  pages={10123-8}
}
Posttranslational N-terminal protein arginylation, mediated by Arg-tRNA-protein transferase 1 (ATE1), is essential for cardiovascular development and angiogenesis in mammals but is nonessential in yeast. Evidence suggests that many proteins are arginylated in vivo in both mammals and yeast; however, in yeast, N-terminal arginylation can occur only on proteins bearing an N-terminal Asp or Glu, whereas in mammals, N-terminal Cys residues are also arginylation targets, suggesting that Cys… CONTINUE READING

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