Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction.

@article{Ishida2005IdentificationOM,
  title={Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction.},
  author={A. Yoshihisa Ishida and Yukiyo Tada and Takaki Nimura and Noriyuki Sueyoshi and Tsuyoshi Katoh and Masayuki Takeuchi and Hitoshi Fujisawa and Takanobu Taniguchi and Isamu Kameshita},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={435 1},
  pages={134-46}
}
Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP) is a unique protein phosphatase that specifically dephosphorylates and regulates multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs). To clarify the physiological significance of CaMKP, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and fructose bisphosphate aldolase as major binding partners of CaMKP in a soluble fraction of rat brain using the two-dimensional far-Western blotting technique, in… CONTINUE READING