Identification of lysyl oxidase and other platelet-derived growth factor-inducible genes in vascular smooth muscle cells by differential screening.

@article{Green1995IdentificationOL,
  title={Identification of lysyl oxidase and other platelet-derived growth factor-inducible genes in vascular smooth muscle cells by differential screening.},
  author={Robert S. Green and Mark E Lieb and Andrea S. Weintraub and Stephen N. Gacheru and Cinara Lerrer Rosenfield and Shalin Shah and Herbert M. Kagan and Matthew S. Taubman},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1995},
  volume={73 4},
  pages={
          476-82
        }
}
BACKGROUND Atherosclerosis and arterial injury are characterized by vascular smooth muscle cell (VSMC) migration and growth and an increase in synthesis of extracellular matrix. Platelet-derived growth factor (PDGF) has been implicated in these processes. This study was designed to identify additional PDGF-regulated genes in VSMC. EXPERIMENTAL DESIGN A cDNA library prepared from PDGF-stimulated rat aortic VSMC was screened by differential hybridization to identify clones representing PDGF… CONTINUE READING

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