Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

  title={Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.},
  author={Sandra S Haenni and Paul O. Hassa and Matthias Altmeyer and Monika Fey and Ralph Imhof and Michael O Hottiger},
  journal={The international journal of biochemistry & cell biology},
  volume={40 10},
Poly-ADP-ribose polymerase-2 (PARP-2) was described to regulate cellular functions comprising DNA surveillance, inflammation and cell differentiation by co-regulating different transcription factors. Using an in vitro and in vivo approach, we identified PARP-2 as a new substrate for the histone acetyltransferases PCAF and GCN5L. Site directed mutagenesis indicated that lysines 36 and 37, located in the nuclear localization signal of PARP-2, are the main targets for PCAF and GCN5L activity in… CONTINUE READING


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