Corpus ID: 40113856

Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.

@article{Khachik1997IdentificationOL,
  title={Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.},
  author={Frederick Khachik and Paul S. Bernstein and Donita L. Garland},
  journal={Investigative ophthalmology \& visual science},
  year={1997},
  volume={38 9},
  pages={
          1802-11
        }
}
PURPOSE To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing their high-performance liquid chromatography (HPLC)-ultraviolet/visible absorption spectrophotometry (UV/Vis)-mass spectrometry (MS) profile with those of authentic standards prepared by organic… Expand
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Chromatograms of retinal extracts, obtained by HPLC on three different stationary phases, were found to match those obtained with mixtures of lutein and zeaxanthin standards. Expand
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