Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements.

@article{Mueller2008IdentificationOL,
  title={Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements.},
  author={Imke Mueller and Cord Beeger and Catherine Alix-Panabi{\`e}res and Xavier R{\'e}billard and Klaus Pantel and Heidi Schwarzenbach},
  journal={Clinical chemistry},
  year={2008},
  volume={54 4},
  pages={
          688-96
        }
}
BACKGROUND Accurate identification of loss of heterozygosity (LOH) on circulating free DNA is often restricted by technical limitations such as poor quality and quantity of tumor-specific DNA and contamination by normal DNA. However, plasma DNA may harbor tumor-specific genetic alterations and could therefore be an interesting target for noninvasive examinations of tumor DNA. METHODS By PCR-based fluorescence microsatellite analysis using 12 polymorphic markers, we investigated LOH on cell… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

A critical evaluation of loss of heterozygosity detected in tumor tissues, blood serum and bone marrow plasma from patients with breast cancer

H Schwarzenbach, V Müller, +3 authors K. Pantel
  • Breast Cancer Res 2007;9:R66
  • 2007

Comparison of genetic alterations detected in circulating microsatellite-DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia

I Müller, K Urban, K Pantel, H. Schwarzenbach
  • Circulating Nucleic Acids in Plasma/Serum and Serum Proteomics IV. Ann N Y Acad Sci 2006;1075:222–9
  • 2006

Detection and quantification of mutations in the plasma of patients with colorectal tumors.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005