Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.

@article{Blackford2012IdentificationOL,
  title={Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.},
  author={John A Blackford and Chunhua Guo and Rong Lan Zhu and Edward J. Dougherty and C. Channing Chow and S. Stoney Simons},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 49},
  pages={40982-95}
}
A currently obscure area of steroid hormone action is where the component factors, including receptor and reporter gene, act. The DNA binding of factors can be precisely defined, but the location and timing of factor binding and action are usually not equivalent. These questions are addressed for several factors (e.g. glucocorticoid receptor (GR), reporter, TIF2, NCoR, NELF-A, sSMRT, and STAMP) using our recently developed competition assay. This assay reveals both the kinetically defined… CONTINUE READING

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