Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury.

@article{Silliman2011IdentificationOL,
  title={Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury.},
  author={Christopher C. Silliman and Ernest Eugene Moore and Marguerite R. Kelher and Samina Yasmin Khan and Lauren Gellar and David J. Elzi},
  journal={Transfusion},
  year={2011},
  volume={51 12},
  pages={2549-54}
}
BACKGROUND Lipids accumulate during the storage of red blood cells (RBCs), prime neutrophils (PMNs), and have been implicated in transfusion-related acute lung injury (TRALI). These lipids are composed of two classes: nonpolar lipids and lysophosphatidylcholines based on their retention time on separation by high-pressure liquid chromatography. Prestorage leukoreduction significantly decreases white blood cell and platelet contamination of RBCs; therefore, it is hypothesized that prestorage… CONTINUE READING

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Prestorage leukoreduction significantly decreases white blood cell and platelet contamination of RBCs ; therefore , it is hypothesized that prestorage leukoreduction changes the classes of lipids that accumulate during storage , and these lipids prime PMNs and induce acute lung injury ( ALI ) as the second event in a two - event in vivo model .
Prestorage leukoreduction significantly decreases white blood cell and platelet contamination of RBCs ; therefore , it is hypothesized that prestorage leukoreduction changes the classes of lipids that accumulate during storage , and these lipids prime PMNs and induce acute lung injury ( ALI ) as the second event in a two - event in vivo model .
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