Identification of ligands for two human bitter T2R receptors.

@article{Pronin2004IdentificationOL,
  title={Identification of ligands for two human bitter T2R receptors.},
  author={Alexey N. Pronin and Huixian Tang and Judy Connor and Walter Keung},
  journal={Chemical senses},
  year={2004},
  volume={29 7},
  pages={583-93}
}
Earlier, a family of G protein-coupled receptors, termed T2Rs, was identified in the rodent and human genomes through data mining. It was suggested that these receptors mediate bitter taste perception. Analysis of the human genome revealed that the hT2R family is composed of 25 members. However, bitter ligands have been identified for only three human receptors so far. Here we report identification of two novel ligand-receptor pairs. hT2R61 is activated by 6-nitrosaccharin, a bitter derivative… CONTINUE READING

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