Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance.

@article{Hong2012IdentificationOL,
  title={Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance.},
  author={Văn Th{\`a}nh Ho{\`a}ng and Abraham Zepeda-Moreno and Anthony D. Ho},
  journal={Biotechnology journal},
  year={2012},
  volume={7 6},
  pages={
          779-88
        }
}
Acute myeloid leukemia (AML) is considered to be a disease of stem cells. A rare defective stem cell population is purported to drive tumor growth. Similarly to their normal counterparts, leukemic stem cells (LSC) divide extreme slowly. This may explain the ineffectiveness of conventional chemotherapy in combatting this disease. Novel treatment strategies aimed at disrupting the binding of LSC to stem cell niches within the bone marrow might render the LSC vulnerable to chemotherapy and thus… CONTINUE READING
BETA

Similar Papers

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

CD123 and its potential clinical application in leukemias.

  • Life sciences
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

Leukemia cells induce changes in human bone marrow stromal cells

  • Journal of Translational Medicine
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 93 REFERENCES

Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL