Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance

@article{Hong2012IdentificationOL,
  title={Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance},
  author={V. T. Ho{\`a}ng and Abraham Zepeda-Moreno and A. Ho},
  journal={Biotechnology Journal},
  year={2012},
  volume={7}
}
  • V. T. Hoàng, Abraham Zepeda-Moreno, A. Ho
  • Published 2012
  • Biology, Medicine
  • Biotechnology Journal
  • Acute myeloid leukemia (AML) is considered to be a disease of stem cells. A rare defective stem cell population is purported to drive tumor growth. Similarly to their normal counterparts, leukemic stem cells (LSC) divide extreme slowly. This may explain the ineffectiveness of conventional chemotherapy in combatting this disease. Novel treatment strategies aimed at disrupting the binding of LSC to stem cell niches within the bone marrow might render the LSC vulnerable to chemotherapy and thus… CONTINUE READING
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    References

    SHOWING 1-10 OF 96 REFERENCES
    Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • 1,077
    • Highly Influential
    • PDF
    Leukemia stem cells
    • E. Buss, A. Ho
    • Biology, Medicine
    • International journal of cancer
    • 2011
    • 108
    CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia
    • 294
    • Highly Influential
    • PDF
    Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance.
    • 33
    Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies
    • 52
    • PDF
    A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia.
    • 341
    • PDF
    Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice.
    • 318
    • PDF
    CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
    • 925
    • Highly Influential
    • PDF
    Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • 6,105
    • PDF
    Stem cell gene expression programs influence clinical outcome in human leukemia
    • 737