Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance

  title={Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance},
  author={V. T. Ho{\`a}ng and Abraham Zepeda-Moreno and A. Ho},
  journal={Biotechnology Journal},
  • V. T. Hoàng, Abraham Zepeda-Moreno, A. Ho
  • Published 2012
  • Biology, Medicine
  • Biotechnology Journal
  • Acute myeloid leukemia (AML) is considered to be a disease of stem cells. A rare defective stem cell population is purported to drive tumor growth. Similarly to their normal counterparts, leukemic stem cells (LSC) divide extreme slowly. This may explain the ineffectiveness of conventional chemotherapy in combatting this disease. Novel treatment strategies aimed at disrupting the binding of LSC to stem cell niches within the bone marrow might render the LSC vulnerable to chemotherapy and thus… CONTINUE READING
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