Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin.


Nogalamycin is an anthracycline antibiotic that has been shown to exhibit significant cytotoxicity. Its biological activity requires two deoxysugar moieties: nogalose and nogalamine, which are attached at C7 and C1, respectively, of the aromatic polyketide aglycone. Curiously, the aminosugar nogalamine is also connected through a C-C bond between C2 and C5… (More)
DOI: 10.1002/cbic.201100637


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics