Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.

  title={Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.},
  author={Julio C M Ricarte-Filho and Sheng Li and Mar{\'i}a E R Garc{\'i}a-Rendueles and Cristina Montero-Conde and Francesca Voza and Jeffrey A. Knauf and Adriana Heguy and Agnes J. Viale and Tetyana I. Bogdanova and Geraldine Anne Thomas and Christopher E. Mason and James A. Fagin},
  journal={The Journal of clinical investigation},
  volume={123 11},
Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We examined tissues from 26 Ukrainian patients with thyroid cancer who were younger than 10 years of age and living in contaminated areas during the time of the Chernobyl nuclear reactor accident. We identified nonoverlapping somatic driver mutations in all 26 cases through candidate gene assays and next-generation RNA sequencing. We found that 22 tumors harbored fusion oncogenes… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 54 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…