Identification of key genes and construction of microRNA–mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis

@article{Gao2017IdentificationOK,
  title={Identification of key genes and construction of microRNA–mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis},
  author={H. Gao and Huihan Wang and Wei Yang},
  journal={International Journal of Hematology},
  year={2017},
  volume={106},
  pages={99-107}
}
  • H. Gao, Huihan Wang, Wei Yang
  • Published 2017
  • Biology, Medicine
  • International Journal of Hematology
  • Multiple myeloma (MM) is a common hematological malignancy. To identify key genes and microRNAs in MM, we downloaded two gene expression profiles (GSE16558 and GSE47552) and two microRNA expression profiles (GSE17498 and GSE16558) from the Gene Expression Omnibus (GEO) database. A total of 596 differentially expressed genes (DEGs) and 39 differentially expressed microRNAs (DEMs) were screened out. Pathway analysis showed that upregulated genes were mainly enriched in the “B cell receptor… CONTINUE READING
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