Identification of keratin 19‐positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21‐1

@inproceedings{Kawai2017IdentificationOK,
  title={Identification of keratin 19‐positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21‐1},
  author={Takayuki Kawai and Kentaro Yasuchika and Takamichi Ishii and Hokahiro Katayama and Elena Yukie Yoshitoshi and Satoshi Ogiso and Takahito Minami and Yuya Miyauchi and Hidenobu Kojima and Ryoya Yamaoka and Sadahiko Kita and Katsutaro Yasuda and Naoya Sasaki and Ken Fukumitsu and Etsuro Hatano and Shinji Uemoto},
  booktitle={Cancer medicine},
  year={2017}
}
The current lack of an easily measurable surrogate marker of cancer stem cells (CSCs) prevents the clinical application of CSCs for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker associated with transforming growth factor beta (TGFβ)/Smad signaling, and that K19+ HCC-CSCs could be a new therapeutic target of TGFβ receptor 1 inhibitor LY2157299. In this study, we examined whether K19+ HCC-CSCs can be tracked using cytokeratin 19 fragment… CONTINUE READING
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