Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis.

@article{Schwacha1994IdentificationOJ,
  title={Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis.},
  author={Anthony Schwacha and Nancy Kleckner},
  journal={Cell},
  year={1994},
  volume={76 1},
  pages={51-63}
}
We have investigated DNA interactions between homologs and between sister chromatids during meiosis in S. cerevisiae. We have detected a DNA species containing information from both parental chromosomes at a specific hotspot for meiotic recombination and double strand breaks (DSBs). These joint molecules are a prominent feature of meiotic prophase. They appear to be a major intermediate stage in DSB-promoted recombination, because they occur with appropriate timing and require known… CONTINUE READING
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