Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency

@article{Heffern2019IdentificationOI,
  title={Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency},
  author={Elleard Heffern and Rashmi Ramani and Garland R. Marshall and George B. Kyei},
  journal={Journal of Virus Eradication},
  year={2019},
  volume={5},
  pages={84 - 91}
}
Abstract Objectives Current antiretroviral therapy can suppress HIV replication, increase CD4 count and result in increased lifespan. However, it cannot eradicate the virus due to the presence of latent provirus in cellular reservoirs, such as resting CD4+ T cells. Using combination latency-reversing agents to shock the virus out of latency for elimination through immune clearance or viral cytopathic effect is one of the most promising strategies for HIV eradication. Specifically, recent… Expand
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