Identification of intrathymic T progenitor cells by expression of Thy-1, IL2 receptor and CD3.

Abstract

Immature (L3T4-/Lyt-2- "double-negative") thymocytes were separated into several functionally distinct fractions based on their expression of IL2 receptors, Thy-1 and CD3. The majority (60-70%) of double-negative thymocytes in young adult mice lack detectable IL2 receptor expression, have high levels of Thy-1 and rapidly "progress" to a L3T4+ or L3T4+/Lyt-2… (More)

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