Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography.

@article{Guiffant2007IdentificationOI,
  title={Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography.},
  author={Damien Guiffant and D{\'e}borah Tribouillard and Fabienne Gug and Herv{\'e} Galons and Laurent Meijer and Marc Blondel and St{\'e}phane Bach},
  journal={Biotechnology journal},
  year={2007},
  volume={2 1},
  pages={68-75}
}
Efforts to characterize small molecular weight chemical inhibitors of pharmacological interest tend to identify molecules with high efficiency and selectivity, to meet the two criteria required for the clinical development of a drug: efficacy and harmlessness. Drug candidates are expected to inhibit efficiently the target they have been optimized against (for example, a particular type of protein kinase). These hits are also designed to not interfere (or as little as possible) with the activity… CONTINUE READING
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