Identification of intracellular factor XIII in human monocytes and macrophages.

  title={Identification of intracellular factor XIII in human monocytes and macrophages.},
  author={Peter Henriksson and Susannne Becker and Gary Lynch and J Mcdonagh},
  journal={The Journal of clinical investigation},
  volume={76 2},
Factor XIII is a blood protransglutaminase that is distributed in plasma and platelets. The extracellular and intracellular zymogenic forms differ in that the plasma zymogen contains A and B subunits, while the platelet zymogen has A subunits only. Both zymogens form the same enzyme. Erythrocytes, in contrast, contain a tissue transglutaminase that is distinct from Factor XIII. In this study other bone marrow-derived cells were examined for transglutaminase activity. Criteria that were used to… CONTINUE READING


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