Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders.

@article{Glinskii2009IdentificationOI,
  title={Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders.},
  author={Anna B. Glinskii and Jun Ma and Shuang Ping Ma and Denise Grant and C. Lim and Stewart Sell and Gennadi V. Glinsky},
  journal={Cell cycle},
  year={2009},
  volume={8 23},
  pages={3925-42}
}
Meta-analysis of genomic coordinates of SNP variations identified in genome-wide association studies (GWAS) of up to 712,253 samples (comprising 221,158 disease cases, 322,862 controls, and 168,233 case/control subjects of obesity GWAS) reveals that 39% of SNPs associated with 22 common human disorders are located within intergenic regions. Chromatin-state maps based on H3K4me3-H3K36me3 signatures show that many intergenic disease-linked SNPs are located within the boundaries of the K4-K36… CONTINUE READING
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