Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera.

@article{Prince2007IdentificationOI,
  title={Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera.},
  author={Harry E. Prince and Mary Lap{\'e}-Nixon and Carol Audette and Kenneth G Van Horn},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={190 1-2},
  pages={165-9}
}
Clinical studies demonstrate differences in interferon-beta (IFNbeta) antibody detection frequencies among multiple sclerosis patients receiving different IFNbeta products. We sought to determine if these differences are also found when IFNbeta antibodies are measured in a reference laboratory, where factors normally controlled in clinical studies are unknown. Serum IFNbeta binding antibodies (BAbs) were quantitated by ELISA; BAbs-positive samples were then tested in a bioassay for neutralizing… CONTINUE READING

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