Identification of intercellular cell adhesion molecule 1 (ICAM-1) as a hypoglycosylation marker in congenital disorders of glycosylation cells.

@article{He2012IdentificationOI,
  title={Identification of intercellular cell adhesion molecule 1 (ICAM-1) as a hypoglycosylation marker in congenital disorders of glycosylation cells.},
  author={Ping He and Bobby G Ng and Marie-Estelle Losfeld and WenHong Zhu and Hudson H. Freeze},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 22},
  pages={18210-7}
}
Many human inherited disorders cause protein N-glycosylation defects, but there are few cellular markers to test gene complementation for such defects. Plasma membrane glycoproteins are potential biomarkers because they may be reduced or even absent in plasma membranes of glycosylation-deficient cells. We combined stable isotope labeling by amino acids in cell culture (SILAC) with linear ion trap mass spectrometry (LTQ Orbitrap(TM)) to identify and quantify membrane proteins from wild-type CHO… CONTINUE READING

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