Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.

@article{Almind2003IdentificationOI,
  title={Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.},
  author={Katrine Almind and Rohit N. Kulkarni and Scott M Lannon and C Ronald Kahn},
  journal={Diabetes},
  year={2003},
  volume={52 6},
  pages={1535-43}
}
Mice double heterozygous (DH) for deletion of insulin receptor and insulin receptor substrate-1 are lean, insulin resistant, and have a phenotype that strongly depends on the genetic background of the mouse. On the C57BL/6 (B6) background, DH mice develop marked hyperinsulinemia and diabetes, whereas on the 129S6 background, DH mice exhibit only mild elevations of insulin and remain free of diabetes. F2 male mice created by an intercross between these two strains exhibit a 60% incidence of… CONTINUE READING

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