Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.

@article{Schubert2008IdentificationOI,
  title={Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.},
  author={Steffen Wolfgang Schubert and Nicolas Lamoureux and Karin Kilian and Ludger Klein-Hitpass and Said Hashemolhosseini},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 9},
  pages={5460-5}
}
Members of the GCM (glial cells missing) transcription factor family have been shown to act as master regulators in different cells during mammalian and fly development being responsible for processes including gliogenesis, hematopoiesis, placental formation, and development of the parathyroidea. In the central nervous system of flies, several target genes for GCM have been reported, namely repo, pointed, and tramtrack. In mammals, two GCM genes are known (GCMa and GCMb), but the knowledge of… CONTINUE READING