Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.

@article{Gietzen1999IdentificationOI,
  title={Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.},
  author={K F Gietzen and David M Virshup},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 45},
  pages={32063-70}
}
Casein kinase I epsilon (CKIepsilon) is a widely expressed protein kinase implicated in the regulation of diverse cellular processes including DNA replication and repair, nuclear trafficking, and circadian rhythm. CKIepsilon and the closely related CKIdelta are regulated in part through autophosphorylation of their carboxyl-terminal extensions, resulting in down-regulation of enzyme activity. Treatment of CKIepsilon with any of several serine/threonine phosphatases causes a marked increase in… CONTINUE READING

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