Identification of in vivo released products of Onchocerca with diagnostic potential, and characterization of a dominant member, the OV1CF intermediate filament.

@article{ChoNgwa2011IdentificationOI,
  title={Identification of in vivo released products of Onchocerca with diagnostic potential, and characterization of a dominant member, the OV1CF intermediate filament.},
  author={Fidelis Cho-Ngwa and Xiang Zhu and Jonathan Alunge Metuge and Annika Daggfeldt and Kjell-Olov Gr{\"o}nvik and Ronald Orlando and James A Atwood and Vincent Pryde Kehdinga Titanji},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2011},
  volume={11 4},
  pages={778-83}
}
A sensitive and specific test for the routine diagnosis of active Onchocerca infection is currently lacking. A major drawback in the development of such a test has been the paucity of knowledge of suitable parasite antigens that can serve as targets in antigen-detection assays. In the present investigation, we employed mass spectrometry, bioinformatics and molecular techniques to identify and characterize several potentially diagnostic Onchocerca antigens in the in vivo nodular fluid, which is… CONTINUE READING

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