Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

@article{Douglas2002IdentificationOI,
  title={Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.},
  author={Pauline Douglas and Gopal P Sapkota and Nick Morrice and Yaping Yu and Aaron A Goodarzi and Dennis Merkle and Katheryn Meek and Dario R Alessi and Susan P Lees-Miller},
  journal={The Biochemical journal},
  year={2002},
  volume={368 Pt 1},
  pages={243-51}
}
The DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA double-strand breaks (DSBs), such as those caused by ionizing radiation and other DNA-damaging agents. DNA-PK is composed of a large catalytic subunit (DNA-PKcs) and a heterodimer of Ku70 and Ku80 that assemble on the ends of double-stranded DNA to form an active serine/threonine protein kinase complex. Despite in vitro and in vivo evidence to support an essential role for the protein kinase activity of DNA-PK in the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Identification and characterization of four novel phosphorylation sites ( Ser 31 , Ser 325 , Thr 336 and Thr 366 ) on LKB 1 / STK 11 , the protein kinase mutated in Peutz - Jeghers cancer syndrome

D. R. Alessi, N. Gomez, +3 authors P. Cohen
Biochem . J • 2002

Sequence analysis of 193 . 4 and 83 . 9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc ( DNA - PKcs ) gene

A. Fujimori, R. Araki, +5 authors M. Abe
Radiat . Res . • 2002

Sequence analysis of 193.4

M. Mori, R. Fukumura, T Ohhata
2002

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