Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography/mass spectrometry.

@article{Shi2013IdentificationOI,
  title={Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography/mass spectrometry.},
  author={Xiaowei Shi and Man Liu and Min Zhang and Kerong Zhang and Songchen Liu and Shi Zhang Qiao and Rui Shi and Xijuan Jiang and Qiao Wang},
  journal={Food chemistry},
  year={2013},
  volume={141 1},
  pages={357-65}
}
The objective of the present study was to develop a practical strategy for the identification of metabolites following the in vivo metabolism and in vitro microbial biotransformation of isoimperatorin using liquid chromatography hybrid triple quadrupole-linear ion trap mass spectrometry (LC/QTRAP-MS) and liquid chromatography time of flight mass spectrometry (LC/TOF-MS). As a result, 19 metabolites were characterised in rat urine, plasma, bile and faeces after the oral administration of… CONTINUE READING