Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

@inproceedings{Smith2011IdentificationOI,
  title={Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort},
  author={Katherine R. Smith and Vijayaprakash Suppiah and K. O'Connor and Thomas Berg and Martin D Weltman and Maria Lorena Abate and Ulrich Spengler and Margaret Fiona Bassendine and Gail V. Matthews and William Lucien Irving and Elizabeth E Powell and Stephen Mark Riordan and Golo Ahlenstiel and Graeme John Stewart and Melanie Bahlo and J George and David M. Booth},
  booktitle={Genome Medicine},
  year={2011}
}
The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard of care therapy is currently pegylated interferon alpha and ribavirin (PegIFN/R), which is effective in less than half of those infected with the most common viral genotype. Two IL28B single nucleotide polymorphisms (SNPs), rs8099917 and rs12979860, predict response to (PegIFN/R) therapy in treatment of HCV infection. These SNPs were identified in genome wide analyses using… CONTINUE READING
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