Identification of immunogenic proteins in Treponema phagedenis-like strain V1 from digital dermatitis lesions by phage display.

@article{Rosander2011IdentificationOI,
  title={Identification of immunogenic proteins in Treponema phagedenis-like strain V1 from digital dermatitis lesions by phage display.},
  author={Anna Rosander and Bengt Guss and Lars Frykberg and Camilla Bj{\"o}rkman and Katarina N{\"a}slund and M Jodeane Pringle},
  journal={Veterinary microbiology},
  year={2011},
  volume={153 3-4},
  pages={315-22}
}
Digital dermatitis (DD) is a contagious claw disease causing lameness in cattle, affecting both animal welfare and economics. In this study, shotgun phage display was used to identify immunogenic proteins in a strain (V1) of the Treponema phylotype closely related to Treponema phagedenis, indicated as a key agent in the pathogenesis of DD. A genomic phage library was constructed and selected against antibodies from a rabbit immunized with live strain V1 bacteria. A homolog to the immunogenic… CONTINUE READING

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