Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.

@article{He2004IdentificationOI,
  title={Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.},
  author={Yuxian He and Yusen Zhou and Hao Wu and Baojun Luo and Jingming Chen and Wanbo Li and Shibo Jiang},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={4050-7}
}
The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is not only responsible for receptor binding and virus fusion, but also a major Ag among the SARS-CoV proteins that induces protective Ab responses. In this study, we showed that the S protein of SARS-CoV is highly immunogenic during infection and immunizations, and contains five linear immunodominant sites (sites I to V) as determined by Pepscan analysis with a set of synthetic peptides overlapping the… CONTINUE READING