Identification of imine reductase-specific sequence motifs.

@article{Fademrecht2016IdentificationOI,
  title={Identification of imine reductase-specific sequence motifs.},
  author={Silvia Fademrecht and Philipp N. Scheller and Bettina M Nestl and Bernhard Hauer and J{\"u}rgen Pleiss},
  journal={Proteins},
  year={2016},
  volume={84 5},
  pages={600-10}
}
Chiral amines are valuable building blocks for the production of a variety of pharmaceuticals, agrochemicals and other specialty chemicals. Only recently, imine reductases (IREDs) were discovered which catalyze the stereoselective reduction of imines to chiral amines. Although several IREDs were biochemically characterized in the last few years, knowledge of the reaction mechanism and the molecular basis of substrate specificity and stereoselectivity is limited. To gain further insights into… CONTINUE READING