Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry.

@article{Voss2004IdentificationOH,
  title={Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry.},
  author={Andrew A Voss and Jozsef Lango and Michael A Ernst-Russell and Dexter Morin and Isaac N Pessah},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 33},
  pages={34514-20}
}
The skeletal-type ryanodine receptor (RyR1) undergoes covalent adduction by nitric oxide (NO), redox-induced shifts in cation regulation, and non-covalent interactions driven by the transmembrane redox potential that enable redox sensing. Tight redox regulation of RyR1 is thought to be primarily mediated through highly reactive (hyperreactive) cysteines. Of… CONTINUE READING