Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.

Abstract

Recent studies show that the extrahepatic human UDP-glucuronosyltransferase (UGT)1A10 is capable of phase II glucuronidation of several major cytochrome P450 metabolites of warfarin (i.e., 6-, 7-, and 8-hydroxywarfarin). This study expands on this finding by testing the hypothesis that the UGT1A10 F(90)-M(91)-V(92)-F(93) amino acid motif is important for… (More)
DOI: 10.1124/dmd.108.022863

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@article{Miller2008IdentificationOH, title={Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.}, author={Grover Paul Miller and Cheryl F. Lichti and Agnieszka K. Zielinska and Anna Mazur and Stacie M. Bratton and Anna Gallus-Zawada and Moshe Finel and Jeffery H. Moran and Anna Radomińska-Pandya}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2008}, volume={36 11}, pages={2211-8} }