Identification of hydrophobic tags for the degradation of stabilized proteins.

@article{Tae2012IdentificationOH,
  title={Identification of hydrophobic tags for the degradation of stabilized proteins.},
  author={Hyun Seop Tae and Thomas Sundberg and Taavi K. Neklesa and Devin J. Noblin and Jeffrey L Gustafson and Anke Gundula Roth and Kanak Raina and Craig M Crews},
  journal={Chembiochem : a European journal of chemical biology},
  year={2012},
  volume={13 4},
  pages={
          538-41
        }
}
New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36. 

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