Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

@article{Lehmann2011IdentificationOH,
  title={Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.},
  author={Brian D. Lehmann and Joshua A Bauer and Xi Chen and Melinda E Sanders and A. Bapsi Chakravarthy and Yu Shyr and Jennifer A. Pietenpol},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 7},
  pages={2750-67}
}
Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast cancer data sets and identified 587 TNBC cases. Cluster analysis identified 6 TNBC subtypes displaying unique GE and ontologies, including 2 basal-like (BL1 and BL2), an immunomodulatory (IM), a mesenchymal (M), a mesenchymal stem-like (MSL), and a luminal androgen receptor (LAR… CONTINUE READING
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