Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR.


In order to identify human lineage specific (HLS) copy number differences (CNDs) compared to other primates, we performed pair wise comparisons (human vs. chimpanzee, gorilla and orangutan) by using cDNA array comparative genomic hybridization (CGH). A set of 23 genes with HLS duplications were identified, as well as other lineage differences in gene copy… (More)
DOI: 10.1016/j.ygeno.2010.02.003