Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease

@article{HarariSteinberg2013IdentificationOH,
  title={Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease},
  author={O. Harari-Steinberg and S. Metsuyanim and D. Omer and Y. Gnatek and Rotem Gershon and Sara Pri-Chen and Derya D. Ozdemir and Y. Lerenthal and Tzahi Noiman and H. Ben-Hur and Z. Vaknin and D. Schneider and B. Aronow and R. Goldstein and P. Hohenstein and B. Dekel},
  journal={EMBO Molecular Medicine},
  year={2013},
  volume={5},
  pages={1556 - 1568}
}
  • O. Harari-Steinberg, S. Metsuyanim, +13 authors B. Dekel
  • Published 2013
  • Biology, Medicine
  • EMBO Molecular Medicine
  • Identification of tissue‐specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell‐based therapies for renal disease. In the human kidney, stem/progenitor cells are induced into the nephrogenic pathway to form nephrons until the 34 week of gestation, and no equivalent cell types can be traced in the adult kidney. Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth of human foetal kidneys in serum‐free defined… CONTINUE READING
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