Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease

@inproceedings{HarariSteinberg2013IdentificationOH,
  title={Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease},
  author={Orit Harari-Steinberg and Sally Metsuyanim and Dorit Omer and Yehudit Gnatek and Rotem Gershon and S Pri-chen and Derya Deniz Ozdemir and Yaniv Lerenthal and Tzahi Noiman and Herzel Ben-Hur and Zvi Vaknin and David F. Schneider and Bruce J. Aronow and Ronald S Goldstein and Peter Hohenstein and Benjamin Dekel},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Identification of tissue-specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell-based therapies for renal disease. In the human kidney, stem/progenitor cells are induced into the nephrogenic pathway to form nephrons until the 34 week of gestation, and no equivalent cell types can be traced in the adult kidney. Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth of human foetal kidneys in serum-free defined… CONTINUE READING

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