Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.

@article{Andersson1994IdentificationOH,
  title={Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.},
  author={Tommy Andersson and John O. Miners and M. E. Veronese and Donald Birkett},
  journal={British journal of clinical pharmacology},
  year={1994},
  volume={37 6},
  pages={597-604}
}
1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic pathways and identify the cytochrome P450 (CYP) isoforms responsible for the formation of the secondary metabolites of omeprazole. 2. The major secondary omeprazole metabolite was the hydroxysulphone, which was formed during incubation with both hydroxyomeprazole and omeprazole sulphone. A second metabolite, tentatively identified as pyridine-N-oxide omeprazole sulphone, was… CONTINUE READING

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