Identification of human immunodeficiency virus primary isolates resistant to interferon-alpha and correlation of prevalence to disease progression.

@article{Knzi1995IdentificationOH,
  title={Identification of human immunodeficiency virus primary isolates resistant to interferon-alpha and correlation of prevalence to disease progression.},
  author={M S K{\"u}nzi and Homayoon Farzadegan and Joseph B. Margolick and David Vlahov and P. M. Pitha},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={171 4},
  pages={822-8}
}
Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon (IFN)-alpha 2 in vitro. These isolates displayed a broad range of sensitivity to IFN-alpha 2. The prevalence of IFN-alpha 2 resistance was low in the absence of AIDS but dramatically increased once HIV infection progressed to AIDS. Although there was no linear correlation between the percentage of IFN-alpha 2 inhibition in vitro and the… CONTINUE READING

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