Identification of human hepatocellular carcinoma-related proteins by proteomic approaches.

  title={Identification of human hepatocellular carcinoma-related proteins by proteomic approaches.},
  author={Ming-Hui Yang and Yu-Chang Tyan and Shiang-Bin Jong and Ying-Fong Huang and Pao-Chi Liao and Ming-chen Wang},
  journal={Analytical and bioanalytical chemistry},
  volume={388 3},
Hepatocellular carcinoma (HCC) is the most common malignant liver tumor. Analysis of human serum from HCC patients using two-dimensional gel electrophoresis (2DE) combined with nano-high-performance liquid chromatography electrospray ionization tandem mass spectrometry (nano-HPLC-ESI-MS/MS) identified fourteen different proteins differentially expressed between HCC patients and the control group. Twelve proteins were up-regulated and two down-regulated. By using nano-HPLC-MS/MS system to… CONTINUE READING
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