Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas.

@article{Victora2012IdentificationOH,
  title={Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas.},
  author={Gabriel D Victora and David Dominguez-Sola and Antony B. Holmes and Stephanie Deroubaix and Riccardo Dalla-Favera and Michel C. Nussenzweig},
  journal={Blood},
  year={2012},
  volume={120 11},
  pages={
          2240-8
        }
}
Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection. GCs are polarized into dark (DZ) and light zones (LZ), a distinction that is of key importance to GC selection. However, the difference between the B cells in each of these zones in humans remains unclear. We show that, as in mice, CXCR4 and CD83 can be used to distinguish human LZ and DZ cells. Using these markers, we show that LZ and DZ cells in mice and humans differ only in the expression of… CONTINUE READING

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