Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

@article{Huskey1995IdentificationOH,
  title={Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.},
  author={S W Huskey and Dennis C Dean and Randall R Miller and G H Rasmusson and S. L. Chiu},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 10},
  pages={1126-35}
}
Finasteride, a prescription drug for the treatment of benign prostatic hypertrophy and alleviation of symptoms associated with benign prostatic hypertrophy and alleviation of symptoms associated with benign prostatic hypertrophy, has been shown to be metabolized in rat hepatic microsomes by hydroxylation at the t-butyl group (omega-OH finasteride), followed by further oxidation to the corresponding acid (omega-oic acid finasteride), with omega-aldehyde finasteride as an intermediate. In this… CONTINUE READING