Identification of human brain tumour initiating cells

  title={Identification of human brain tumour initiating cells},
  author={Sheila K Singh and Cynthia Hawkins and Ian D. Clarke and Jeremy A Squire and Jane Bayani and Takuichiro Hide and R. Mark Henkelman and Michael D. Cusimano and Peter Dirks},
The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties. Although the existence of CSCs in human leukaemia is established, little evidence exists for CSCs in solid tumours, except for breast cancer. Recently, we prospectively isolated a CD133+ cell subpopulation from human brain tumours that exhibited stem cell properties in vitro. However, the true measures of CSCs are their capacity for self renewal… CONTINUE READING
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