Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck.

@article{Visus2007IdentificationOH,
  title={Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck.},
  author={Carmen Visus and Diasuke Ito and Andrew Anthony Amoscato and Malgorzata Maciejewska-Franczak and Ahmed Abdelsalem and Rajiv Dhir and Dong M Shin and Vera S Donnenberg and Theresa L Whiteside and Albert B. Deleo},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={
          10538-45
        }
}
Few epitopes are available for vaccination therapy of patients with squamous cell carcinoma of the head and neck (SCCHN). Using a tumor-specific CTL, aldehyde dehydrogenase 1 family member A1 (ALDH1A1) was identified as a novel tumor antigen in SCCHN. Mass spectral analysis of peptides in tumor-derived lysates was used to determine that the CTL line recognized the HLA-A*0201 (HLA-A2) binding ALDH1A1(88-96) peptide. Expression of ALDH1A1 in established SCCHN cell lines, normal mucosa, and… CONTINUE READING

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