Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

  title={Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.},
  author={Erik A. Nelson and Sarah R. Walker and Wei Li and Xiaole Shirley Liu and David M. Frank},
  journal={The Journal of biological chemistry},
  volume={281 36},
STAT5 is a transcription factor essential for hematopoietic physiology. STAT5 functions to transduce signals from cytokines to the nucleus where it regulates gene expression. Although several important transcriptional targets of STAT5 are known, most remain unidentified. To identify novel STAT5 targets, we searched chromosomes 21 and 22 for clusters of STAT5 binding sites contained within regions of interspecies homology. We identified four such regions, including one with tandem STAT5 binding… CONTINUE READING


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