Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

@article{Clayton1989IdentificationOH,
  title={Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding},
  author={L. Clayton and M. Sieh and D. Pious and E. Reinherz},
  journal={Nature},
  year={1989},
  volume={339},
  pages={548-551}
}
INTERACTIONS of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny1 and subsequently for helper and cytotoxic functions of CD4+CD8− T lymphocytes2–5. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp1206–10. The residues involved in gp120 binding have been localized to a region within the immunoglobulin-like domain I of CD4, which corresponds to CDR2 of an immunoglobulin variable region11… Expand
The class II MHC and HIV-1 binding surfaces of CD4.
CD4/immunoglobulin interaction: implications for immune physiology and autoimmunity.
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References

SHOWING 1-10 OF 37 REFERENCES
The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia.
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.
...
1
2
3
4
...