Identification of host proteins required for HIV infection through a functional genomic screen.

  title={Identification of host proteins required for HIV infection through a functional genomic screen.},
  author={Abraham L. Brass and Derek Michael Dykxhoorn and Yair Benita and Nan Yan and Alan N. Engelman and Ramnik J. Xavier and Judy Lieberman and Stephen J Elledge},
  volume={319 5865},
HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs). These proteins participate in a broad array of cellular functions and implicate new pathways in the viral life cycle. Further analysis revealed previously unknown roles for retrograde Golgi transport proteins (Rab6 and Vps53) in viral entry, a karyopherin (TNPO3) in viral integration… CONTINUE READING
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