Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.


A major challenge to clinical therapy of Burkholderia cepacia complex (Bcc) pulmonary infections is their innate resistance to a broad range of antimicrobials, including polycationic agents such as aminoglycosides, polymyxins, and cationic peptides. To identify genetic loci associated with this phenotype, a transposon mutant library was constructed in B… (More)
DOI: 10.1128/AAC.00602-11